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Article

Unveiling the prognostic and immunological role of IFI44 in glioma.

Annals of medicine - 1 Dec 2025

Jin Die, Mao Liangliang, Wu Yanke, Tang Tingting, Yan Enhui, Song Zekai

Abstract excerpt

BACKGROUND: Gliomas are aggressive central nervous system tumors with limited understanding of their molecular drivers. Identifying novel prognostic and therapeutic biomarkers remains crucial. METHODS: Using TCGA, GTEx, GEO, and CGGA datasets, we performed differential expression, Cox regression, and LASSO analyses to identify prognostic genes. IFI44, one of eight significant candidates, was analyzed for its...

Read the complete abstract on PubMed

Topics

Humans
Glioma
Prognosis
Tumor Microenvironment
Biomarkers, Tumor
Brain Neoplasms
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Proliferation

Cell Line, Tumor

Male

Mutation

Female

Cell Movement

Gene Expression Profiling

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 41327009
DOI: 10.1080/07853890.2025.2593209
PMCID: PMC12673984

Genes

IFI44
CIC
CTLA4
IDH1
LAG3
NF1
NOTCH1

Provenance

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