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Article

Screening of the founder pathogenic variants BRCA1 and BRCA2 in Russian metropolitan women.

BMC women's health - 26 Nov 2025

Bodunova Natalia, Bilyalov Airat, Danishevich Anastasiia, Kvetenadze Gurami, Andronov Artem, Starshinin Andrey, Rumyantsev Konstantin, Zhukova Ludmila, Khripun Alexey, Khatkov Igor

Abstract excerpt

BACKGROUND: Hereditary cancer and associated high risk genetic variants accountable for 5-10% of all breast cancer cases carry a significant burden on the health system and the pathogenic variants carriers. The harm from these factors can be significantly reduced through the timely detection of genetic alterations and implementation of health monitoring programs for pathogenic variants carriers. METHODS: We...

Read the complete abstract on PubMed

Topics

Humans
Female
Middle Aged
Adult
Genetic Testing
Breast Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

BRCA2 Protein

BRCA1 Protein

Russia

Prospective Studies

Genetic Predisposition to Disease

Founder Effect

Aged

Early Detection of Cancer

Source

Open in PubMed Open full text

Identifiers

PMID: 41299556
DOI: 10.1186/s12905-025-04164-6
PMCID: PMC12713268

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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