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Article

POLE-mutated atypical endometrial hyperplasia in an adolescent: a 5-year follow-up with LNG-IUS-a case report and literature review.

BMC women's health - 25 Nov 2025

Liu Jun, Han Yanhua, Wu Siyun

Abstract excerpt

This case report describes a rare instance of atypical endometrial hyperplasia (AEH) in a 16-year-old adolescent female presenting with secondary amenorrhea lasting 3 years. Imaging studies demonstrated a honeycomb-like intrauterine mass abutting the endometrial-myometrial junction, measuring 60 mm in length and 33 mm in maximal thickness. Diagnosis of POLE-mutated AEH (WHO 2020 criteria) was confirmed via...

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Topics

Humans
Female
Adolescent
Levonorgestrel
Endometrial Hyperplasia
Intrauterine Devices, Medicated
Follow-Up Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 41291685
DOI: 10.1186/s12905-025-04139-7
PMCID: PMC12648797

Genes

POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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