Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-ancestry investigation of the genomics of erectile dysfunction.

Nature communications - 24 Nov 2025

Bright Uri, Chen Yu, Deak Joseph D, Zhou Hang, Levey Daniel F, Gelernter Joel

Abstract excerpt

Erectile dysfunction is attributable to numerous biological and psychological issues, and its prevalence increases with age. We conducted genome-wide association studies of erectile dysfunction in AllofUs subjects of European and African ancestry, then meta-analyzed our findings with published datasets [NEuropean = 913,194 (136,867 cases); NAfrican = 125,315 (51,599 cases)]. We identified 40 independent variants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Proteins
Share to Black People
Share to Erectile Dysfunction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Genomics

Share to Polymorphism, Single Nucleotide

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 41285899
DOI: 10.1038/s41467-025-66723-7
PMCID: PMC12749275

Genes

SIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-ancestry investigation of the genomics of erectile dysfunction.PMID 41285899Read ↗

GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in EtiologySemantic proximity Read ↗

Sexual differences in genetic architecture in UK BiobankSemantic proximity Read ↗

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brainSemantic proximity Read ↗

[Genetic aspects of erectile dysfunction].Semantic proximity Read ↗

The Genetics and Epidemiology of Female Sexual Dysfunction: A ReviewSemantic proximity Read ↗

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brainSemantic proximity Read ↗

Discovery of Novel Trans-Ancestry and Ancestry-Specific Gene Loci for Total Testosterone in a Multi-Ancestral Analysis of Men in the Million Veteran ProgramSemantic proximity Read ↗

A genome-wide association study of female sexual dysfunction.Semantic proximity Read ↗

A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for erectile dysfunction.Semantic proximity Read ↗

Differential DNA Methylation in Monozygotic Twins Discordant for Female Sexual Functioning.Semantic proximity Read ↗

Assessing Genetic Risk of DKK3 and SLAMF6 in Erectile Dysfunction: A Comprehensive Analysis Based on Mendelian Randomization.Semantic proximity Read ↗

Replication study identified EFEMP1 association with varicose vein predisposition among Indians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.