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Article

Germline genomic testing to assess the suitability of stem cell donors in the treatment of haematological malignancy: clinical ethics commentary.

Journal of medical ethics - 22 Sept 2026

Carley Helena, Sahan Kate, Hanson Helen, Snape Katie, Westbury Sarah, Parker Michael J, Lucassen Anneke M

Abstract excerpt

The increasing integration of genomic medicine into routine medical care brings to light issues of complexity and uncertainty in the interpretation of genetic variation.We describe a fictional case study based on our experiences in the haematological malignancy setting to illustrate the complexities in using genomic testing to evaluate the suitability of relatives to act as stem cell donors. In particular, we...

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Topics

Humans
Genetic Testing
Hematologic Neoplasms
Germ-Line Mutation
Tissue Donors
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Decision Making

Female

Donor Selection

Ethical Dilemmas

Source

Open in PubMed Open full text

Identifiers

PMID: 41266114
DOI: 10.1136/jme-2025-111111
PMCID: PMC7619150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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