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Article

CRISPR-Cas-associated SCCmec Variants in Methicillin-resistant Staphylococcus aureus Evade Rapid Diagnostic Detection.

The Journal of infectious diseases - 18 Feb 2026

Podkowik Magdalena, Tillman Alice, Takats Courtney, Carion Heloise, Putzel Gregory, McWilliams Julian, See Benjamin, Wang Guiqing, Munoz-Gomez Sigridh, Otto Caitlin, Drlica Karl, Marraffini Luciano, Pironti Alejandro, Hochman Sarah, Kerantzas Christopher, Shopsin Bo

Abstract excerpt

Rapid molecular assays guiding treatment of methicillin-resistant Staphylococcus aureus detect SCCmec (Xpert) or the SCCmec-orfX junction (BCID2). Sequence variation in this region can disrupt primer binding, yielding false-negative results. Investigation of a missed bloodstream infection linked escape to a CRISPR-Cas-associated SCCmec variant, leading to identification of 64 variants from 45 patients-2% of 2432...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41254867
DOI: 10.1093/infdis/jiaf575
PMCID: PMC13017219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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