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Article

Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia.

The Journal of investigative dermatology - 1 Jun 2026

Keller-Rosenthal Noy, Sarig Ofer, Giladi Moshe, Malovitski Kiril, Rubinstein Rotem, Haitin Yoni, Larrondo Jorge, Lenzy Yolanda, Dlova Ncoza, McMichael Amy, Sprecher Eli

Abstract excerpt

Central centrifugal cicatricial alopecia (CCCA) is the most common form of primary scarring alopecia in women of African descent, typically characterized by progressive hair loss originating at the vertex of the scalp. Although genetic susceptibility has been implicated in the pathogenesis of CCCA, only 1 gene (PADI3, encoding peptidyl arginine deiminase 3) has been thus far associated with CCCA. This study aimed...

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Source

Identifiers

PMID: 41242654
DOI: 10.1016/j.jid.2025.10.609

Genes

PADI3
S100A3
TCHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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