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Article

GBA1 Variants with Unknown Classification Are Modest Contributors to Parkinson's Disease Susceptibility.

Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2026

Parlar Sitki Cem, Lee Yoomin, Gan-Or Ziv

Abstract excerpt

BACKGROUND: GBA1 variants cause Gaucher's disease (GD) in biallelic forms and increase Parkinson's disease (PD) risk in heterozygous carriers. Carriers of mild or severe variants (causing GD type 1 or types 2-3) can enroll in clinical trials, whereas those with GBA1 variants classified as unknown are typically excluded. OBJECTIVE: We assessed the contribution of unknown variants to PD risk and their relevance for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41239902
DOI: 10.1002/mds.70127
PMCID: PMC13022579

Genes

GBA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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