Phenotypically driven subgroups of primary antiphospholipid syndrome-associated thrombocytopenia display distinct outcomes: a prospective cohort study with cluster analysis.

doi:10.1136/lupus-2025-001761

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Article

Phenotypically driven subgroups of primary antiphospholipid syndrome-associated thrombocytopenia display distinct outcomes: a prospective cohort study with cluster analysis.

Lupus science & medicine - 13 Nov 2025

Li Jun, Mo Ruijie, Huang Can, Zhou Yangzhong, Peng Liying, Jiang Hui, Shi Yu, Ding Yufang, Zhao Yan, Zeng Xiaofeng, Li Mengtao, Zhao Jiuliang

Abstract excerpt

OBJECTIVES: To identify antiphospholipid antibody-associated thrombocytopenia (aPLs-TP) phenotypes and assess their clinical outcomes. METHODS: This single-centre, prospective cohort study (January 2012 to April 2024) consecutively enrolled patients with aPLs-TP from Peking Union Medical College Hospital. Inclusion required persistent aPL positivity (≥12 weeks apart) and platelet (PLT) count <100×109/L twice,...

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Topics

Humans
Female
Male
Adult
Thrombocytopenia
Prospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Antiphospholipid Syndrome

Phenotype

Middle Aged

Pregnancy

Cluster Analysis

Platelet Count

Antibodies, Antiphospholipid

Thrombosis

Kaplan-Meier Estimate

Source

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Identifiers

PMID: 41238374
DOI: 10.1136/lupus-2025-001761
PMCID: PMC12625884

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