Article
Identification of phenotypes in thrombotic primary antiphospholipid syndrome using cluster analysis: a step toward personalized medicine.
Journal of thrombosis and haemostasis : JTH - 1 Oct 2025
Santos Gabrielle M, David Paula, Hen Or, Ontiveros-Austria Juan Luis, Liran Rotem, Rodriguez-Rodriguez Sergio, Cerchiari de Godói Julia, Patt Yonatan Shneor, Beladev Shaked, Okazaki Erica, Collela Marina, Stefanello Bianca, Yamaguti-Hayakawa Gabriela G, Rothschild Cynthia, Annichino-Bizzachi Joyce, Vargas-Ruiz Angel, Prestes Paula, Rocha Vanderson, de Paula Erich V, Gendelman Omer, Salomon Ophira, Demichelis-Gomez Roberta, Barrera-Vargas Ana, Amital Howard, Villaça Paula, Shoenfeld Yehuda, Orsi Fernanda A
Abstract excerpt
BACKGROUND: Thrombotic risk in primary antiphospholipid syndrome (APS) is a result of complex, yet undefined, interactions among multiple factors. While long-term anticoagulation reduces thrombotic complications, its efficacy varies, with thrombosis recurrence rates ranging from 5% to 20% within 2 years. Emerging therapies may benefit specific APS subgroups, although identifying and stratifying these groups...
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