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Article

Bipolar and major depressive disorders: associations with serum zonulin levels and rs2070937 polymorphism.

BMC psychiatry - 13 Nov 2025

Baykan Ozgur, Akbas Furkan, Solmaz Avcikurt Ayla, Baykan Hayriye

Abstract excerpt

BACKGROUND: The underlying pathophysiology of bipolar disorder and major depressive disorder is not fully understood. Inflammation is increasingly recognized as a contributing factor. The gut plays a central role in this process. Increased intestinal permeability, which promotes inflammation, is regulated by tight junctions and influenced by the zonulin protein. This mechanism has been linked to both inflammatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41233834
DOI: 10.1186/s12888-025-07548-y
PMCID: PMC12613481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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