Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of HLA-DRA-CREB3L4 regulatory axis in the pathogenesis of ovarian endometriosis: Inhibition of CREB3L4 expression by HLA-DRA increases the risk of disease.

Journal of reproductive immunology - 1 Dec 2025

Song Weiwei, Jin Sisi, Wang Gang, Zhou Yining, Yu Juan

Abstract excerpt

BACKGROUND: Ovarian endometriosis is a common gynecological condition characterized by the abnormal growth of endometrial-like tissue in locations outside the uterus, and its development remains poorly understood. This study aims to investigate potential protein regulatory networks and assess their impact on disease risk using both protein quantitative trait locus (pQTL) analysis and Mendelian randomization (MR)...

Read the complete abstract on PubMed

Topics

Humans
Female
Endometriosis
Cyclic AMP Response Element-Binding Protein
Quantitative Trait Loci
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Ovarian Diseases

Genome-Wide Association Study

Gene Expression Regulation

Gene Regulatory Networks

Source

Identifiers

PMID: 41232153
DOI: 10.1016/j.jri.2025.104798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of HLA-DRA-CREB3L4 regulatory axis in the pathogenesis of ovarian endometriosis: Inhibition of CREB3L4 expression by HLA-DRA increases the risk of disease.PMID 41232153Read ↗

The effects of plasma protein levels on the risk of endometriosis: A Mendelian randomization study.Semantic proximity Read ↗

Identification of potential druggable targets for endometriosis through Mendelian randomization analysis.Semantic proximity Read ↗

Mendelian randomization Identifies RSPO3 in Serum as a Potential Target for EndometriosisSemantic proximity Read ↗

The Causal Relationship Between the Levels of 91 Circulating Inflammatory Proteins and Ovarian-Related Diseases: A Bidirectional Mendelian Randomization Study.Semantic proximity Read ↗

Identification of Endometriosis Pathophysiologic-related Genes Based on Meta-analysis and Bayesian ApproachSemantic proximity Read ↗

Identification of Endometriosis Pathophysiologic-Related Genes Based on Meta-Analysis and Bayesian Approach.Semantic proximity Read ↗

Genetic variation perspective reveals potential drug targets for subtypes of endometrial cancer.Semantic proximity Read ↗

Gene expression analysis in endometriosis: Immunopathology insights, transcription factors and therapeutic targetsSemantic proximity Read ↗

The role of calcium homeostasis in endometriosis: a comprehensive study of multiple types of Mendelian randomizationSemantic proximity Read ↗

The role of immune cell signatures in the pathogenesis of ovarian-related diseases: a causal inference based on Mendelian randomizationSemantic proximity Read ↗

Genetic evidence for causal effects of immune cell traits on risk for endometriosis: a bidirectional two-sample Mendelian Randomization StudySemantic proximity Read ↗

Causal Genes and Immune-Epigenetic Mechanisms Underlying Polycystic Ovary Syndrome: A Multi-Omics Mendelian Randomization StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.