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Article

Genetic variation perspective reveals potential drug targets for subtypes of endometrial cancer.

Scientific reports - 15 Nov 2024

Zhu Jiamei, Zhang Ting, Jiang Juan, Yang Mei, Xia Nan, Chen Youguo

Abstract excerpt

The study aims to identify potential drug targets for endometrial cancer (EC) subtypes through a Mendelian randomization (MR) approach, assessing their clinical relevance. We utilized genetic instruments for 4,907 plasma proteins from the deCODE Genetics study dataset, and data with EC (n = 12,906) from a genome-wide study (GWAS) meta-analysis in European populations for MR analyses. Complementary analyses...

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Identifiers

PMID: 39548148
DOI: 10.1038/s41598-024-78689-5
PMCID: PMC11568156

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