Article
Association of the GPx-3 + 1494 A/G gene polymorphism with serum trace elements in psoriasis vulgaris.
Irish journal of medical science - 1 Feb 2026
Yukcu Fulya, Yildiz Mustafa, Akcilar Raziye, Bas Aycan, Namdar Nazlı Dizen
Abstract excerpt
BACKGROUND: Psoriasis vulgaris (PV) is a chronic inflammatory skin disorder in which oxidative stress, redox imbalance, and genetic susceptibility play crucial roles. Glutathione peroxidase-3 (GPx-3), a selenium-dependent antioxidant enzyme, regulates redox homeostasis by detoxifying reactive oxygen species. Variants in the GPx-3 gene may alter antioxidant defense and trace element metabolism, thereby...
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