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Article

Dutch participatory surveillance framework for evaluating evolutionary changes on SARS-CoV-2 affecting rapid diagnostic test sensitivity in 2022 - 2023.

BMC infectious diseases - 5 Nov 2025

Kozanli Eva, Han Wanda, Smit Tara, de Bakker Jordy, Elahi Mansoer, Jaarsma Ryanne, Carstens Gesa, van Hoek Albert Jan, Eggink Dirk

Abstract excerpt

BACKGROUND: Rapid Diagnostic Tests (RDTs) for SARS-CoV-2 have been pivotal for diagnostics, and shaping policies regarding self-isolation. In case of decreased sensitivity of RDTs to novel virus variants, viral spread can increase. In order to monitor for reduced sensitivity of RDTs we used a collection of SARS-CoV-2 positive samples from RDT negative patients. Infectieradar, a national participatory surveillance...

Read the complete abstract on PubMed

Topics

Humans
COVID-19
SARS-CoV-2
Netherlands
Sensitivity and Specificity
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Adult

Middle Aged

COVID-19 Testing

Diagnostic Tests, Routine

Mutation

False Negative Reactions

Aged

Young Adult

Evolution, Molecular

Rapid Diagnostic Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 41194062
DOI: 10.1186/s12879-025-11888-1
PMCID: PMC12587668

Genes

NTS

Provenance

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