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Can symptom-severity phenotypes identify depression risk after mild traumatic brain injury? A cluster-based approach.

BMC psychiatry - 4 Nov 2025

Chen Hung-Ju, Ma Ching-Yuan, Lin Li-Fan, Chang Cheng-Chiang, Hueng Dueng-Yuan, Chang Yue-Cune, Chiang Hui-Hsun

Abstract excerpt

BACKGROUND: Mild traumatic brain injury (mTBI) affects millions worldwide and frequently leads to secondary depression. Early identification of high-risk individuals is critical for targeted mental-health screening in this population. Data-driven phenotyping offers a promising avenue to unmask hidden symptom patterns, but few studies have combined unsupervised clustering of post-concussion profiles with...

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PMID: 41188789
DOI: 10.1186/s12888-025-07512-w
PMCID: PMC12584339

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