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Article

Predicted protein 3D structures provide essential insights into the genetic architecture underlying phenotypic diversity in maize.

Genome research - 5 Jan 2026

Wang Shuai, Khaipho-Burch Merritt, Johnson Lynn C, Miller Zachary R, Bradbury Peter J, Speed Doug, Allen William J, Romay M Cinta, Xue Jiquan, Buckler Edward S, Ramstein Guillaume P, Song Baoxing

Abstract excerpt

Variation in protein 3D structures reflects genetic variation and contributes to phenotypic diversity, yet its underlying genetic mechanisms remain unclear. To investigate the relationship between protein 3D structure and phenotype, we predict the 3D structures of 795,649 proteins from 26 maize (Zea mays L.) inbred lines using AlphaFold2. Population genetics analysis of these protein 3D structures reveal that...

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Identifiers

PMID: 41173509
DOI: 10.1101/gr.280514.125
PMCID: PMC12758397

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