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Article

A retrospective analysis of clinicopathological and genetic features of synchronous CNS and systemic DLBCL at diagnosis.

International journal of hematology - 1 Feb 2026

Ohashi Kayo Egoshi, Fukuhara Suguru, Maeshima Akiko Miyagi, Shibata Maki, Makino Haruhi, Hattori Daiki, Sasaki Hirokazu, Makita Shinichi, Iwaki Noriko, Munakata Wataru, Fukuda Takahiro, Ando Miki, Izutsu Koji

Abstract excerpt

Synchronous central nervous system (CNS) and systemic diffuse large B-cell lymphoma (synDLBCL) is a rare, aggressive entity with poor prognosis and limited data guiding optimal management. We retrospectively analyzed 25 patients with synDLBCL treated at our institution between 2012 and 2021. Among the 20 patients undergoing curative-intent treatment, most received less-intensive CNS-directed therapies, including...

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Identifiers

PMID: 41171506
DOI: 10.1007/s12185-025-04089-8

Genes

CD79B
MYD88

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