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Article

Pathophysiological mechanisms linking osteoarthritis and neurodegenerative disease risk.

Osteoarthritis and cartilage - 1 Feb 2026

Prasoon Pranav, Nguyen Kayla L, Fathi Payam A, Gupta Shruti, Arnab Sreejita, Jones Erin, Meyyappan Aravind, Stehle Elena J, Bethea John R

Abstract excerpt

OBJECTIVE: This review aims to assess the existing evidence that connects osteoarthritis (OA) with neurodegenerative diseases, specifically Alzheimer's disease (AD) and Parkinson's disease (PD), and to elucidate shared mechanisms that may contribute to the development of innovative therapeutic approaches. METHOD: We present a narrative review of prior epidemiological, genetic, and mechanistic studies that...

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Identifiers

PMID: 41167327
DOI: 10.1016/j.joca.2025.10.009

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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