Article
Ginsenoside Derivative AD-1 Suppresses Pathogenic Phenotypes of Rheumatoid Arthritis Fibroblast-like Synoviocytes by Modulating the PI3K/Akt Signaling Pathway.
Cells - 18 Oct 2025
Fu Yuan, Li Fangfang, Cui Biao, Zhou Zhongyu, Fang Xizhu, Huang Shengnan, Quan Xingguo, Zhao Yuqing, Jin Dan
Abstract excerpt
Rheumatoid arthritis (RA) is a systemic autoimmune disorder marked by chronic inflammation of small synovial joints, with frequent extra-articular involvement of the skin and eyes. Prolonged methotrexate therapy for RA is often accompanied by serious side effects. Therefore, new drugs with less toxicity and greater effectiveness need to be developed. The ginsenoside 20(R)-25-methoxyl-dammarane-3β,12β,20-triol...
Read the complete abstract on PubMedTopics
- Ginsenosides
- Arthritis, Rheumatoid
- Humans
- Synoviocytes
- Proto-Oncogene Proteins c-akt
- Phosphatidylinositol 3-Kinases