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Vitamin D Deficiency and VDR Gene Variants in Polycystic Ovary Syndrome: A Case-Control Study.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Nov 2025

Chakraborty Sanchari, Pal Randrita, Begum Farzana, Naskar Tapan Kumar, Das Nilansu, Basu Barnali Ray

Abstract excerpt

Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder in reproductive-aged women and adolescents. Vitamin D deficiency (VDD) and genetic variations in the vitamin D receptor (VDR) pronouncedly influence its manifestations. The interplay between VDD and VDR polymorphisms has an umbrella effect on the endocrine and metabolic milieu of PCOS, underscoring the importance of vitamin D (VD) in its...

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PMID: 41126011
DOI: 10.1007/s43032-025-01991-8

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VDR

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