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Article

Evaluation of BRAF V600E and TERT mutation analysis in differential thyroid cancers.

Updates in surgery - 1 Apr 2026

Aktash Nigar, Dural Ahmet Cem, Aydin Husnu, Sahbaz Nuri Alper, Guzey Deniz, Altınay Serdar, Akarsu Cevher, Kesgin Yasir Musa, Bulut Sezer, Karabulut Mehmet

Abstract excerpt

The objective of this study to evaluate the potential effects of Differentiated Thyroid Cancer (DTC), BRAF V600E oncogene, and TERT promoter mutation association, on the clinical course and aggressive spread of the tumor. A total of 137 patients with DTC, who had surgery, were evaluated retrospectively. The patients were grouped as DTC with the aggressive course (Group 1), DTC with the standard course (Group 2),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Neoplasm Invasiveness

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins B-raf

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Share to Thyroid Neoplasms

Source

Identifiers

PMID: 41125874
DOI: 10.1007/s13304-025-02448-y

Genes

BRAF
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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In Japanese patients with papillary thyroid carcinoma, TERT promoter mutation is associated with poor prognosis, in contrast to BRAF V600E mutation.Semantic proximity Read ↗

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