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Efficacy and tolerability of a low-glycemic-index ketogenic diet in Angelman syndrome: findings from the DIANE study

21 Oct 2025

Abstract excerpt

AIM: This study evaluates the efficacy of a low-glycemic-index diet (LGID) in improving neurodevelopmental and sleep outcomes in pediatric Angelman Syndrome (AS) patients. METHOD: A prospective, evaluator-blinded cohort study was conducted with 20 pediatric patients (3-16 years) diagnosed with AS. Patients were assigned to an LGID or habitual diet group and followed for 24 weeks. The primary outcome was...

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PMID: 41121232
DOI: 10.1186/s13023-025-04037-z

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