Pangenome analysis of Tanzanian clinical Klebsiella pneumoniae reveals pandemic clones with high genome plasticity and versatile mobilome, virulome, and resistome profiles.

Abstract excerpt

Klebsiella pneumoniae is a rapidly evolving pathogen with a diverse pangenome whose mobilome and resistome remain elusive. Here, we aimed to delineate the pangenome of 198 isolates from Tanzanian regions. Raw Illumina reads retrieved from public repositories were assembled and analyzed using multilocus sequence typing, core-genome single nucleotide polymorphism (SNP)-based phylogeny, and capsular polysaccharide...

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