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Article

Novel Identification of Genetic Variants in Musculoskeletal Pathways Implicated in Familial Femoroacetabular Impingement.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Dec 2025

Wyles Cody C, Trousdale William H, Paradise Christopher R, Trousdale Robert T, Klee Eric W, Sierra Rafael J

Abstract excerpt

Femoroacetabular impingement (FAI) of the hip results from altered morphology of the proximal femur and/or acetabulum, creating abnormal contact between these structures during normal hip range of motion. The etiology of this structural phenotype is unknown. This study aimed to identify common single-nucleotide variants (SNVs) among two families with seemingly heritable FAI. Additionally, this study examined...

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PMID: 41110123
DOI: 10.1002/jor.70088

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