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Pangenome analysis of Lactobacillus mulieris strains reveals distinct subspecies clusters with defined ecological adaptations.

Microbiology spectrum - 4 Nov 2025

Montecillo Jake Adolf V, Yoo Heon Jong, Lee Yoo-Young, Park Chul Min, Cho Angela, Lee Hyunsu, Yoon Hee Yeon, Kim Jong Mi, Lee Nan Young, Park Sun-Hyun, Park Nora Jee-Young, Han Hyung Soo, Seo Incheol, Chong Gun Oh

Abstract excerpt

Lactobacillus mulieris is a recently described species, reportedly isolated from human urine, vagina, and gut. Previous genomic studies of L. mulieris highlighted significant genetic diversity among its strains. To gain a deeper understanding of this genomic diversity, we conducted a comprehensive genomic comparison of 70 L. mulieris strains from diverse sources. Phylogenomic and genome relatedness analysis...

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Topics

Humans
Phylogeny
Genome, Bacterial
Adaptation, Physiological
Lactobacillus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Vagina

Genetic Variation

Multigene Family

Urine

Genomics

Source

Open in PubMed Open full text

Identifiers

PMID: 41036850
DOI: 10.1128/spectrum.02011-25
PMCID: PMC12584728

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