Article
Integrated molecular data analysis confirms PDK1 as a candidate risk factor in ALS pathophysiology.
Molecular brain - 1 Oct 2025
Liu Yuqian, Guo Ruiyun, Wang Ni, Yang Yue, Li Jialu, Jing Danyang, Cui Ruoyan, Ma Runchao, Ma Jun
Abstract excerpt
Combining cellular, animal, and MR analyses from three independent cohorts, we identified PDK1 as a consistent risk factor for ALS development, highlighting its potential as a therapeutic target. To further elucidate PDK1's pathogenic mechanisms, we conducted transcriptomic profiling. Samples were stratified into PDK1 high- and low-expression groups. GO and KEGG analyses demonstrated that upregulated DEGs were...
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