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Article

Elevated maternal testosterone induces sex-specific neurodevelopmental changes and ASD-related behavioral phenotypes in rat offspring.

Pediatric research - 1 Jun 2026

Mishra Jay S, Bhamidipati Sai Krishna, Ross Jordan Ronald, Dangudubiyyam Sri Vidya, Samanta Jayshree, Kumar Sathish

Abstract excerpt

OBJECTIVE: Elevated maternal testosterone (T) during pregnancy disrupts neurodevelopment and behavior in offspring, mimicking features of autism spectrum disorder (ASD). METHODS: In a rat study, dams received daily T injections (0.5 mg/kg) from gestational days 12-20, doubling maternal plasma T to mimic levels seen in pregnancy complications. Controls received vehicle. Offspring were assessed neonatally...

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Identifiers

PMID: 41034646
DOI: 10.1038/s41390-025-04425-y
PMCID: PMC13221296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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