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Article

Associations of Sleep Pattern and Genetic Risk with Late-Onset Psoriasis: A Large Prospective Cohort Study.

The Journal of investigative dermatology - 1 May 2026

Zhang Yan, Huang Yuzhou, Jing Danrong, Liang Huaying, Tian Yuzi, Zhou Guowei, Zhang Guanxiong, Shen Minxue, Xiao Yi, Chen Xiang, Liu Hong

Abstract excerpt

Whether sleep disturbance is associated with the risk of incident psoriasis, and whether this association exists in the presence of different genetic risk levels remain unknown. To examine the sleep-gene interaction in association with risk of psoriasis, we conducted a prospective cohort study that recruited >500,000 participants from 2006 to 2010 using data from the UK Biobank. A sleep pattern was defined by...

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PMID: 41033481
DOI: 10.1016/j.jid.2025.08.048

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