Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation.

Human genetics - 1 Sept 2007

Lettre Guillaume, Butler Johannah L, Ardlie Kristin G, Hirschhorn Joel N

Abstract excerpt

Stature (adult height) is one of the most heritable human traits, yet few genes, if any, have been convincingly associated with adult height variation in the general population. Here, we selected 150 tag SNPs from eight candidate genes in the growth hormone (GH)/insulin-like growth factor-1 (IGF1) axis (GHR, GHRH, GHRHR, IGF1, IGFALS, IGFBP3, JAK2, STAT5B), and genotyped them in approximately 2,200 individuals...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Height
Share to Growth Hormone-Releasing Hormone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor Binding Protein 3

Share to Insulin-Like Growth Factor Binding Proteins

Share to Insulin-Like Growth Factor I

Share to Receptors, Neuropeptide

Share to Receptors, Pituitary Hormone-Regulating Hormone

Share to STAT5 Transcription Factor

Source

Identifiers

PMID: 17546465
DOI: 10.1007/s00439-007-0385-4

Genes

IGF1
GHR
GHRH
GHRHR
IGFALS
IGFBP3
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation.PMID 17546465Read ↗

A genetic study of the ghrelin and growth hormone secretagogue receptor (GHSR) genes and stature.Semantic proximity Read ↗

Genetic causes of isolated short statureSemantic proximity Read ↗

Genetic regulation of adult stature.Semantic proximity Read ↗

Progress in genome-wide association studies of human height.Semantic proximity Read ↗

Towards identification of molecular mechanisms of short statureSemantic proximity Read ↗

The New Genomics: What Molecular Databases Can Tell Us About Human Population Variation and Endocrine Disease.Semantic proximity Read ↗

Using height association studies to gain insights into human idiopathic short and syndromic stature phenotypes.Semantic proximity Read ↗

Common polymorphisms in the GH/IGF-1 axis contribute to growth in extremely tall subjects.Semantic proximity Read ↗

Rare protein-coding variation and the genetic architecture of height in >1.4 million individualsSemantic proximity Read ↗

Association of IGF-1 Levels With Height From Childhood to Adulthood: An Observational and Mendelian Randomization Study.Semantic proximity Read ↗

Defining the role of common variation in the genomic and biological architecture of adult human height.Semantic proximity Read ↗

Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.