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Article

Sequence similarity-based candidate gene prioritization for Type 1 diabetes mellitus using moment of inertia tensor.

Immunologic research - 28 Sept 2025

Vishnu Eesam, Chandramohan Nithya, Manimaran P

Abstract excerpt

In this paper, the study focuses on Type 1 Diabetes Mellitus (T1D), a chronic condition that affects the insulin-producing cells of the pancreas, requiring individuals to depend on external insulin for survival. We introduce a novel method for analyzing protein sequences by treating them as rigid bodies with mass and moment of inertia to assess sequence similarity. This method transforms the protein sequences...

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PMID: 41017002
DOI: 10.1007/s12026-025-09697-4

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