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Article

PB2 and NP of North American H5N1 virus drive immune cell replication and systemic infections.

Science advances - 26 Sept 2025

Kim Young-Il, Jang Seung-Gyu, Kwon Woohyun, Kim Jaemoo, Park Dongbin, Choi Isaac, Choi Jeong Ho, Gil Juryeon, Yu Mina, Jeong Boyeong, Kim Eun-Ha, Kim Se-Mi, Kim Hyunjoon, Ahn Jae-Woo, Hwang Suhee, Heo Seo-Young, Casel Mark Anthony B, Rollon Rare, Fabrizio Thomas, Webby Richard J, Choi Young Ki

Abstract excerpt

The 2022 North American outbreak of 2.3.4.4b H5N1 avian influenza virus revealed substantial mammalian adaptation and pathogenicity, yet mechanisms remain unclear. To address this knowledge gap, we investigated the North American H5N1 strain (GA/W22-145E/22), which demonstrated unique immune cell-mediated systemic dissemination, neuroinvasion, and 100% mortality in ferrets, unlike the nonlethal Eurasian strain...

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Identifiers

PMID: 41004584
DOI: 10.1126/sciadv.ady1208
PMCID: PMC12466913

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