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Article

Sulcal Depth and Genetic Susceptibility Influence Initial Treatment Response in Adults With Attention-Deficit/Hyperactivity Disorder.

Biological psychiatry. Cognitive neuroscience and neuroimaging - 1 Apr 2026

Laatsch Jonathan, David Friederike S, Stein Frederike, Maj Carlo, Forstner Andreas J, Maier Simon, Matthies Swantje, Sobanski Esther, Alm Barbara, Tebartz van Elst Ludger, Krug Axel, Philipsen Alexandra

Abstract excerpt

BACKGROUND: As neurobiological markers gain prominence in guiding personalized treatments, sulcal depth (SD) remains an underexplored yet pivotal factor in neural processing and therapeutic efficacy. While genetic influences shape cortical architecture, their role in modulating the relationship between SD and treatment outcomes remains unclear. In this study, we investigated whether pretreatment SD predicts...

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PMID: 40983149
DOI: 10.1016/j.bpsc.2025.09.012

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