Article
Association Between Pigmentation Heritage and Susceptibility to Experimentally Induced Myopia: Crossbreeding Insights From Albino and Pigmented Guinea Pigs.
Investigative ophthalmology & visual science - 2 Sept 2025
Jiang Liqin, Dan Yee Shan, Myles William E, Seah Sherlyn H Y, Koh James H Z, Khine Myo Thu, Schmetterer Leopold, Barathi Veluchamy A, Hoang Quan V
Abstract excerpt
Purpose: To investigate how pigmentation heritage affects susceptibility to form deprivation myopia (FDM) through crossbreeding myopia-susceptible albino and myopia-resistant pigmented guinea pigs (GPs). Methods: Ninety GPs (albino: n = 29, pigmented: n = 29, F1 crossbred: n = 32) were studied. Eye parameters were measured using retinoscopy and A-scan ultrasound. Scotopic electroretinograms were recorded by...
Topics
- Animals
- Myopia
- Guinea Pigs
- Electroretinography
- Disease Models, Animal
- Sclera
- Tomography, Optical Coherence
- Choroid
- Monophenol Monooxygenase
- Melanins
- Retinoscopy
- Genetic Predisposition to Disease