Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pigmentation and Retinal Pigment Epithelium Thickness: A Study of the Phenotypic and Genotypic Relationships Between Ocular and Extraocular Pigmented Tissues.

Pigment cell & melanoma research - 1 Jul 2025

Julian Thomas H, Fitzgerald Tomas, Birney Ewan, Sergouniotis Panagiotis I

Abstract excerpt

The retinal pigment epithelium (RPE) is a specialised monolayer of pigmented epithelial cells in the outer retina. The extent to which RPE pigmentation is related to that of other tissues remains unclear. We utilised RPE thickness measured using optical coherence tomography (OCT) imaging as an indicator of RPE melanin content. UK Biobank data was used to assess the relationships between RPE thickness and fundus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hair Color

Share to Melanins

Share to Pigmentation

Share to Retinal Pigment Epithelium

Share to Skin Pigmentation

Share to Tomography, Optical Coherence

Source

Open in PubMed Open full text

Identifiers

PMID: 40650424
DOI: 10.1111/pcmr.70038
PMCID: PMC12254877

Genes

RPE
HERC2
OCA2
TYR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pigmentation and Retinal Pigment Epithelium Thickness: A Study of the Phenotypic and Genotypic Relationships Between Ocular and Extraocular Pigmented Tissues.PMID 40650424Read ↗

Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations.Semantic proximity Read ↗

Ethnicity is not biology: retinal pigment score to evaluate biological variability from ophthalmic imaging using machine learningSemantic proximity Read ↗

Genetic variation affects morphological retinal phenotypes extracted from UK Biobank Optical Coherence Tomography imagesSemantic proximity Read ↗

Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biologySemantic proximity Read ↗

Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic healthSemantic proximity Read ↗

Sub-cellular level resolution of common genetic variation in the photoreceptor layer identifies continuum between rare disease and common variation.Semantic proximity Read ↗

Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypesSemantic proximity Read ↗

Sub-cellular level resolution of common genetic variation in the photoreceptor layer identifies continuum between rare disease and common variationSemantic proximity Read ↗

Investigating the genetic architecture of eye colour in a Canadian cohortSemantic proximity Read ↗

Skin Phototype and Disease. A Comprehensive Genetic Approach to Pigmentary Traits Pleiotropy using PRS in the GCAT CohortSemantic proximity Read ↗

Genetic Heritability of Pigmentary Glaucoma and Associations With Other Eye Phenotypes.Semantic proximity Read ↗

Genetic insights into foveal morphology and its associations with pigmentation and age-related macular degenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.