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Article

An interpretable generative multimodal neuroimaging-genomics framework for decoding Alzheimer's disease.

Journal of neural engineering - 30 Sept 2025

Dolci Giorgio, Cruciani Federica, Abdur Rahaman Md, Abrol Anees, Chen Jiayu, Fu Zening, Boscolo Galazzo Ilaria, Menegaz Gloria, Calhoun Vince D

Abstract excerpt

Objective.Alzheimer's disease (AD) is the most prevalent form of dementia worldwide, encompassing a prodromal stage known as mild cognitive impairment (MCI), where patients may either progress to AD or remain stable. The objective of the work was to capture structural and functional modulations of brain structure and function relying on multimodal MRI data and single nucleotide polymorphisms, also in case of...

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Identifiers

PMID: 40961977
DOI: 10.1088/1741-2552/ae087d
PMCID: PMC12481582

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