Mechanisms of fungal pathogenic DNA-activated STING pathway in biofilms and its implication in dental caries onset

Abstract excerpt

Dental caries, a prevalent oral disease, has long been attributed primarily to bacteria, but emerging evidence highlights the critical role of fungi in its pathogenesis. Fungal biofilms, predominantly Candida albicans, release extracellular DNA (eDNA) and DNA-carrying extracellular vesicles (EVs). Together with bacterial eDNA, these form the biofilm matrix and can activate the host cGAS-STING signaling pathway....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Fungal Infections and Studies
• Share to interferon and immune responses
• Share to Legionella and Acanthamoeba research