Targeting Ferroptosis and Cuproptosis in Ulcerative Colitis: Findings from Comprehensive Bioinformatics and Experimental Validation

Abstract excerpt

Ulcerative colitis (UC) is a persistent intestinal disorder with an incompletely defined pathogenesis and increasing prevalence and hospitalization rates in newly industrialized countries. In UC, excessive intestinal epithelial cell death disrupts the mucosal barrier and triggers inflammatory responses. Ferroptosis and cuproptosis are two recently described forms of regulated cell death. Most studies of UC have...

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