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Insufficient telomeric DNA damage response promotes chromosomal instability in aged oocytes

25 Aug 2025

Abstract excerpt

Increased chromosomal instability impairs oocyte quality, contributing to female reproductive aging. The telomeric DNA damage response (DDR) is essential for genomic stability; however, how oocytes respond to telomeric damage remains elusive. Here, we observed that aged human germinal vesicle (GV) oocytes accumulated telomeric DNA damage. We next established a telomeric DNA damage model with CRISPR/Cas9 in mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40930920
DOI: 10.1016/j.scib.2025.08.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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