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Article

Utility of sequencing the erm(41) gene in isolates of Mycobacterium abscessus subsp. abscessus with low and intermediate clarithromycin MICs.

Journal of clinical microbiology - 1 Apr 2015

Brown-Elliott Barbara A, Vasireddy Sruthi, Vasireddy Ravikiran, Iakhiaeva Elena, Howard Susan T, Nash Kevin, Parodi Nicholas, Strong Anita, Gee Martha, Smith Terry, Wallace Richard J

Abstract excerpt

The erm(41) gene confers inducible macrolide resistance in Mycobacterium abscessus subsp. abscessus, calling into question the usefulness of macrolides for treating M. abscessus subsp. abscessus infections. With an extended incubation (14 days), isolates with MICs of ≥8 μg/ml are considered macrolide resistant by current CLSI guidelines. Our goals were to determine the incidence of macrolide susceptibility in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25653399
DOI: 10.1128/JCM.02950-14
PMCID: PMC4365201

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