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Article

Identification of PilD mutants reveals the iterative social evolution in Pseudomonas aeruginosa.

Applied and environmental microbiology - 22 Oct 2025

Qiu Huifang, Zhou Xiaoqing, Dai Weijun

Abstract excerpt

Bacterial pathogenicity is influenced by the genetic mutations that arise within the population, among which quorum-sensing (QS) is one of the key targets. Recent studies have reported that mutations in the global transcriptional regulator gene mexT can revert QS activity in QS-inactive LasR mutants, thereby transforming the LasR cheater mutants deficient in public goods production into cooperators. However, the...

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PMID: 40905714
DOI: 10.1128/aem.00915-25
PMCID: PMC12542647

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