Circular RNAs accumulate in aging human placental tissue and in stillbirth, leading to DNA damage and cellular senescence

Abstract excerpt

BACKGROUND: Unexplained stillbirth may occur owing to premature placental aging, with an unexpected deterioration of placental function for the gestational age. Circular RNAs are enzyme-resistant RNA molecules that accumulate in aging tissues. Furthermore, circular RNAs bind to genomic DNA directly, forming complexes that can induce DNA breaks and genomic instability. OBJECTIVE: This study investigated tissue...

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