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Recapitulating dengue virus infection with human pluripotent stem cell-derived liver organoids for antiviral screening

28 Aug 2025

Abstract excerpt

Dengue virus (DENV) poses a major global health threat, affecting an estimated 100 to 400 million people annually. The infection and pathogenesis remain incompletely understood, and no antiviral drug is currently approved for DENV treatment. Here, we develop a human pluripotent stem cell (hPSC)-derived liver organoid (hPLO) model to characterize DENV infection and screen for antivirals. The hPLOs, containing...

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PMID: 40877283
DOI: 10.1038/s41467-025-63323-3

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