Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women.

doi:10.1038/s41591-018-0061-3

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Article

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women.

Nature medicine - 1 Jul 2018

Hoyles Lesley, Fernández-Real José-Manuel, Federici Massimo, Serino Matteo, Abbott James, Charpentier Julie, Heymes Christophe, Luque Jèssica Latorre, Anthony Elodie, Barton Richard H, Chilloux Julien, Myridakis Antonis, Martinez-Gili Laura, Moreno-Navarrete José Maria, Benhamed Fadila, Azalbert Vincent, Blasco-Baque Vincent, Puig Josep, Xifra Gemma, Ricart Wifredo, Tomlinson Christopher, Woodbridge Mark, Cardellini Marina, Davato Francesca, Cardolini Iris, Porzio Ottavia, Gentileschi Paolo, Lopez Frédéric, Foufelle Fabienne, Butcher Sarah A, Holmes Elaine, Nicholson Jeremy K, Postic Catherine, Burcelin Rémy, Dumas Marc-Emmanuel

Abstract excerpt

Hepatic steatosis is a multifactorial condition that is often observed in obese patients and is a prelude to non-alcoholic fatty liver disease. Here, we combine shotgun sequencing of fecal metagenomes with molecular phenomics (hepatic transcriptome and plasma and urine metabolomes) in two well-characterized cohorts of morbidly obese women recruited to the FLORINASH study. We reveal molecular networks linking the...

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Identifiers

PMID: 29942096
DOI: 10.1038/s41591-018-0061-3
PMCID: PMC6140997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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