Genetic Variants and Alteration in Transcription Factor 7-Like 2 (TCF7L2) mRNA Level in Ischemic Stroke Patients Among Bengali and Gujarati Population from India.

doi:10.1007/s10528-025-11237-6

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Genetic Variants and Alteration in Transcription Factor 7-Like 2 (TCF7L2) mRNA Level in Ischemic Stroke Patients Among Bengali and Gujarati Population from India.

Biochemical genetics - 1 Jun 2026

Sadhukhan Dipanwita, Roy Arunima, Nath Sukla, Basu Esha, Mukherjee Joydeep, Ghosh Kartik Chandra, Banerjee Tapas Kumar, Krishnan Prasad, Chatterjee Sourya Kishore, Desai Soaham, Patel Vishal Ajitbhai, Ray Debes, Hui Subhra Prakash, Gupta Soma, Biswas Arindam

Abstract excerpt

Diabetes and Hyperlipidemia are major risk factors for stroke across the world population. TCF7L2, a key regulator of the WNT signaling pathway shows genetic association with these metabolic disorders in ethnicity dependant manner. However, its role in stroke pathogenesis (if any) is not well characterized. Here, we aim to (a) investigate and correlate dysregulation of TCF7L2 expression with diabetes or...

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PMID: 40864349
DOI: 10.1007/s10528-025-11237-6

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TCF7L2

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