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Article

Environmental and Inflammatory Factors Drive Perinuclear-Antineutrophil Cytoplasmic Antibodies (pANCA) in Ulcerative Colitis: A European Twin Study.

United European gastroenterology journal - 1 Dec 2025

Bergemalm Daniel, Amcoff Karin, Pierik Marie J, Colombel Jean-Frederic, Vermeire Severine, Bodin Lennart, Carlson Marie, Halfvarson Jonas

Abstract excerpt

BACKGROUND: Perinuclear-antineutrophil cytoplasmic antibodies (pANCA) have been identified in familial ulcerative colitis (UC), but the mechanism underlying their expression remains elusive. We assessed the role of genetic predisposition, environmental factors and systemic subclinical inflammation in the development of pANCA in a twin cohort with UC. METHODS: A total of 48 twin pairs (Leuven, Belgium n = 4,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40839417
DOI: 10.1002/ueg2.70101
PMCID: PMC12704567

Genes

CRP
CDCP1
CXCL9
IL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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