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Co-infection of Helicobacter pylori with Epstein-Barr virus in gastric organoids enhances cell proliferation and morphogenesis

20 Aug 2025

Abstract excerpt

ABSTRACT Helicobacter pylori ( H. pylori ) is a key cause of chronic inflammation and gastric cancer, and Epstein-Barr virus (EBV) also contributes to gastric tumorigenesis. However, the role of EBV co-infection in H. pylori -related cancers remains unclear because of the lack of efficient ex vivo models. Organoids, which are derived from self-renewing stem cells, closely mimic in situ tissue structure and...

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PMID: 40833108
DOI: 10.1128/jvi.00928-25

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