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Article

Independent Clonal Origin in Early-Stage Bilateral Papillary Thyroid Cancer: Evidence From Nuclear and Mitochondrial Genome Analysis.

Molecular carcinogenesis - 1 Nov 2025

Su Xingyun, Yuan Jimeng, Chen Xianmeng, Chen Shitu, Wang Xumeng, Zhou Jie, Teng Lisong, Zhang Feng, Wang Weibin

Abstract excerpt

Papillary thyroid cancer (PTC) often presents as anatomically distinct foci in bilateral lobes. However, it remains controversial whether these foci arise independently from distinct malignant progenitor cells or result from the dissemination of the primary lesion. Fifteen pairs of bilateral PTC at Stage I were enrolled, and sequencing was performed using a 437-cancer-gene panel (Geneseeq). The entire...

Read the complete abstract on PubMed

Topics

Humans
Thyroid Cancer, Papillary
Thyroid Neoplasms
Female
Middle Aged
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Genome, Mitochondrial

Adult

DNA, Mitochondrial

Cell Nucleus

Proto-Oncogene Proteins B-raf

Aged

Neoplasm Staging

Source

Identifiers

PMID: 40831232
DOI: 10.1002/mc.70031

Provenance

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