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TG-Mamba: Leveraging text guidance for predicting tumor mutation burden in lung cancer.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society - 1 Sept 2025

Yu Chunlin, Meng Xiangfu, Li Yinhao, Zhao Zheng, Zhang Yongqin

Abstract excerpt

Tumor mutation burden (TMB) is a crucial biomarker for predicting the response of lung cancer patients to immunotherapy. Traditionally, TMB is quantified through whole-exome sequencing (WES), but the high costs and time requirements of WES limit its widespread clinical use. To address this, we propose a deep learning model named TG-Mamba, capable of rapidly predicting TMB levels based on patients'...

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PMID: 40819605
DOI: 10.1016/j.compmedimag.2025.102626

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TG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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