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Single‐cell transcriptomic analysis reveals a metastasis‐associated PCSK1 + neuroendocrine subpopulation in pancreatic neuroendocrine tumors

16 Aug 2025

Abstract excerpt

Abstract Pancreatic neuroendocrine tumors (PNETs) are uncommon malignancies characterized by significant clinical heterogeneity and a pronounced tendency for liver metastasis. Despite this, the cellular mechanisms driving PNET progression remain inadequately elucidated, especially concerning neuroendocrine subpopulations. We analyzed publicly available single‐cell RNA sequencing (scRNA‐seq) data from 27 samples,...

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PMID: 40817830
DOI: 10.1111/jne.70084

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